Dr. Casey Halpern the Division Head of Functional and Stereotactic Neurosurgery and an Associate Professor of Neurosurgery at Penn.
#40: Casey Halpern – Novel indications and approaches to invasive neuromodulation and neuroscience
In this engaging conversation with Casey Halpern, a functional neurosurgeon at Penn Medicine. Casey is a pioneer in both deep brain stimulation and focused ultrasound and with his lab has recently had some fantastic breakthroughs, especially, but not exclusively in the field of loss-of-control eating in severe obesity. We cover a lot of ground from optogenetics at Stanford, basic science research about the nucleus accumbens and translation of findings into patients, serendipitous discoveries in humans, to stereo-EEG procedures in patients with epilepsy. We discuss what made his recent Nature paper about an appetite mediating circuit in the human hippocampus so special, how he took his findings from 2013 in rodent work – across several stages – into a human clinical trial for eating disorders. We also cover Casey’s ongoing trial in DBS for OCD, where he adopts an approach to probe the brain with multiple electrodes to then identify optimal target areas for each individual patient – in line with other current advances of psychiatric neurosurgery. We also talk about MR guided focused ultrasound and the potential future of this treatment option in a tight relationship with DBS. As always, I learned a lot in this conversation and I hope you find it as enjoyable as I did. Thank you so much for tuning in – for this round episode number 40 of stimulating brains!
References and Links:
- Three papers dicussed during this episode:
- Barbosa, D.A.N., Gattas, S., Salgado, J.S. et al. An orexigenic subnetwork within the human hippocampus. Nature 621, 381–388 (2023).
- Barbosa, D.A.N., Kuijper, F.M., Duda, J. et al. Aberrant impulse control circuitry in obesity. Mol Psychiatry 27, 3374–3384 (2022).
- Shivacharan, R.S., Rolle, C.E., Barbosa, D.A.N. et al. Pilot study of responsive nucleus accumbens deep brain stimulation for loss-of-control eating. Nat Med 28, 1791–1796 (2022).
- Christoffel, D.J., Walsh, J.J., Heifets, B.D. et al. Input-specific modulation of murine nucleus accumbens differentially regulates hedonic feeding. Nat Commun 12, 2135 (2021).
- Media Interviews:
Some pictures showing Dr. Halpern at work and in private life.