#10: Cameron McIntyre – Pushing the frontier of biophysically plausible DBS models
Cameron McIntyre and I talk about biophysically plausible deep brain stimulation models that his laboratory has established and continues to refine since about 20 years. Cameron shares insights from a time where DBS modeling was not a thing – how his career choice to step into the realms of medical hospitals as a biomedical engineer had been risky or at least unusual at the time. We learn why the VTA model was originally a step backwards and why there is a large difference between inventions & prototypes vs. commercially useable products with direct clinical impact. Cameron shares his insight on why DBS modeling for movement disorders and for neuropsychiatric diseases are currently asking very different levels of questions. We touch upon amazing recent inventions by the McIntyre lab – such as the holographic basal ganglia pathway atlas and the HoloDBS system to plan surgeries – collaboratively and remotely from different living rooms throughout the United States.
A picture from the first HoloSEEG planning session with Sameer Sheth and Nader Pouratian
Papers by Cameron McIntyre’s group that we touched upon during the episode include:
- Holographic Pathway Atlas: Petersen, M.V., Mlakar, J., Haber, S.N., Parent, M., Smith, Y., Strick, P.L., Griswold, M.A., McIntyre, C.C., 2019. Holographic Reconstruction of Axonal Pathways in the Human Brain. Neuron 1–13.
Gunalan, K., Chaturvedi, A., Howell, B., Duchin, Y., Lempka, S.F., Patriat, R., Sapiro, G., Harel, N., McIntyre, C.C., 2017. Creating and parameterizing patient-specific deep brain stimulation pathway-activation models using the hyperdirect pathway as an example. PLoS ONE 12, e0176132.
Colleagues mentioned in the episode include:
- Svetlana Miocinovic (Neurologist at Emory University)
- Christopher Butson (Engineer in Salt Lake City)
- Jerrold Vitek (Neurologist in Minnesota)
- Sameer Sheth (Neurosurgeon at Baylor University)
- Nader Pouratian (Neurosurgeon at UCLA)
- Andres Lozano (Neurosurgeon in Toronto)
- Mark Griswold (MR physicist at Case Western University)
- Mikkel Petersen (Neuroscientist at Aarhus / former student of Cameron)
- Suzanne Haber (Neuroanatomist in Rochester)
- Peter Strick (Neuroanatomist in Pittsburgh)
- Martin Parent (Neuroanatomist at Quebec)
- Yoland Smith (Neuropharmacologist & Neuroanatomist at Emory University)
- Jens Volkmann (Neurologist in Würzburg)
- Noam Harel (Neuroscientist in Minnesota)
- Guillermo Sapiro (Electrical Engineer at Duke University)
- Angela Noecker (Neuroscientist at Case Western University)
- Anneke Gilbert (Neuroscientist at Case Western University)